Research

Adequate immune responses control infections, eliminate pathogens and ensure the integrity of the host. In contrast, inadequate immune responses against foreign antigens may lead to the development of allergy while inadequate immune responses against self-antigens may result in the onset of autoimmunity. Accumulating evidence suggests that infections and dysbiosis critically modulate the development of allergy as well as autoimmunity. Although the concepts are intriguing, the underlying mechanisms remain largely elusive.

The MAARS project

MAARS publications and dissemination activities

Journal publications:

Salava A, Lauerma A. Role of the skin microbiome in atopic dermatitis. Clin Transl Allergy. 2014 Oct 17;4:33. doi: 10.1186/2045-7022-4-33. eCollection 2014.

Lauerma A, Salava A. Mikrobiomi – ihon uusi toimija [Microbiome – the skin’s new player] Duodecim. 2014;130(6):613-4.

Salava A, Lauerma A. Hudens mikrobiom – mikroorganismer i nytt ljus? [The skin microbiome – micro-organisms seen under a new light?] Finska Läkaresällskapets Handlingar. 2013, 173(1):18-22.

L. Bennett, A. Kittas, G. Muirhead, L. G. Papageorgiou, S. Tsoka, “Detection of Composite Communities in Multiplex Biological Networks”, Scientific Reports, accepted.

L. Yang, C. Ainali, A. Kittas, F. O. Nestle, L. G. Papageorgiou, S. Tsoka, “Pathway-Level Disease Data Mining through Hyper-box Principles, Math. Biosciences, 260, 25-34, 2015.

L. Bennett, A. Kittas, S. Liu, L. G. Papageorgiou, S. Tsoka, “Community Structure Detection for Overlapping Modules through Mathematical Programming in Protein Interaction Networks”, PLoS ONE, 9(11): e112821, 2014.

L. Yang C. Ainali, S. Tsoka, L. G. Papageorgiou, “Pathway Activity Inference for Multi-class Disease Classification through Mathematical Programming Optimisation Framework”, BMC Bioinformatics, 15, 390, 2014.

J. Kauffman, A. Kittas, L. Bennett, S. Tsoka, “DyCoNet: a Gephi plugin for community detection in dynamic complex networks”, PLoS ONE, 9(7): e101357. doi:10.1371/journal.pone.0101357, 2014.

Elishmereni, M., Bachelet, I., Nissim Ben Efraim, A., Mankuta, D., Levi-Schaffer, F. (2013). Interacting mast cells and eosinophils acquire an enhanced activation state in vitro. Allergy 68:171-179. doi: 10.1111/all.12059.

Elishmereni, M., Fyhrquist, N., Singh Gangwar, R., Lehtimake, S., Aleniu, H., Levi-Schaffer, F. (2014). Complex 2B4 regulation of mast cells and eosinophils in murine allergic inflammation. J. Invest. Dermatol. 134(12):2928-2937. doi: 10.1038/jid.2014.280.

Minai-Fleminger, Y.; Gangwar, R.; Migalovich Sheikhet, H.; Seaf, M.; Leibovici, V..; Hollander, N.; Feld, M.; Moses, A; Homey, B; Levi-Schaffer, F. (2014). The CD48 receptor mediates Staphylococcus aureus human and murine eosinophil activation. Clin. Exp. Allergy 44(11):1335-1346. doi: 10.1111/cea.12422.

Shamri R, Minai-Fleminger Y, Gangwar RS, Migalovich-Sheikhet H, Seaf M, Levi-Schaffer F. (2015). Author response to ’Staphylococcus aureus and primary lysis of eosinophils’ by Dr Persson. Clin Exp Allergy.45(2):490-1. doi: 10.1111/cea.12479

Elishmereni M, Fyhrquist N, Singh Gangwar R, Lehtimäki S, Alenius H, Levi-Schaffer F. Complex 2B4 regulation of mast cells and eosinophils in murine allergic inflammation. J Invest Dermatol. 2014 Dec;134(12):2928-37. doi: 10.1038/jid.2014.280. Epub 2014 Jul 7.

Fyhrquist N, Ruokolainen L, Suomalainen A, Lehtimäki S, Veckman V, Vendelin J, Karisola P, Lehto M, Savinko T, Jarva H, Kosunen TU, Corander J, Auvinen P, Paulin L, von Hertzen L, Laatikainen T, Mäkelä M, Haahtela T, Greco D, Hanski I, Alenius H. Acinetobacter species in the skin microbiota protect against allergic sensitization and inflammation. Allergy Clin Immunol. 2014 Dec;134(6):1301-1309.e11. doi: 10.1016/j.jaci.2014.07.059. Epub 2014 Sep 26.

G.K. Perera, C. Ainali, E. Semenova, C. Hundhausen, G. Barinaga, D. Kassen, A.E. Williams, M.M. Mirza, M. Balazs, X. Wang, R. Sanchez Rodriguez, A. Alendar, J. Barker, S. Tsoka, W. Ouyang, F.O. Nestle, “Integrative Biology Approach Identifies Cytokine Targeting Strategies for Psoriasis”, Sci. Transl. Med. 6, 223ra22 (2014).

Flutter B, Nestle FO. TLRs to cytokines: mechanistic insights from the imiquimod mouse model of psoriasis. Eur J Immunol. 2013 Dec;43(12):3138-46. doi: 10.1002/eji.201343801. Epub 2013 Nov 20.

Villanova F, Flutter B, Tosi I, Grys K, Sreeneebus H, Perera GK, Chapman A, Smith CH, Di Meglio P, Nestle FO. Characterization of Innate Lymphoid Cells in Human Skin and Blood Demonstrates Increase of NKp44+ ILC3 in Psoriasis. J Invest Dermatol. 2014 Apr;134(4):984-91. doi: 10.1038/jid.2013.477. Epub 2013 Nov 11.

Flutter B, Nestle FO. What on ”irf” is this gene 4? Irf4 transcription-factor-dependent dendritic cells are required for T helper 2 cell responses in murine skin. Immunity. 2013 Oct 17;39(4):625-7. doi: 10.1016/j.immuni.2013.09.008.

Savinko T, Karisola P, Lehtimäki S, Lappeteläinen AM, Haapakoski R, Wolff H, Lauerma A, Alenius H. ST2 regulates allergic airway inflammation and T-cell polarization in epicutaneously sensitized mice. J Invest Dermatol. 2013 Nov;133(11):2522-9. doi: 10.1038/jid.2013.195. Epub 2013 Apr 30

Book chapters:

Singh Gangwar, R. and Levi-Schaffer, F. (2014). Eosinophils interaction with mast cells: the allergic effector unit. In: Methods in Molecular Biology (Walsh, G., Ed), Humana Press, USA, 1178:231-249. doi: 10.1007/978-1-4939-1016-8_20.

Landolina, N., Gangwar, R.S., Levi-Schaffer, F. (2015). Mast cells’ integrated actions with eosinophils and fibroblasts in allergic inflammation: implications for therapy. In: Advances in Immunology, (Alt, F., Series Ed.), Elsevier Inc. 125:41-85. doi: 10.1016/bs.ai.2014.09.002

 

Presentations at international conferences:

Lauerma AI. How does skin flora effect dermatitis? European Academy of Allergology and Clinical Immunology (EAACI), Skin Allergy Meeting (SAM), 1.12.2012, Berlin, Germany

Lauerma AI. Skin microbiome in atopic eczema, Annual Meeting of the European Academy of Allergology and Clinical Immunology (EAACI), 8.6.2014, Copenhagen, Denmark

Lauerma AI. Clinical datasets for omics studies. European Academy of Dermatology and Venereology (EADV)/European Society of Dermatological Research (ESDR) Summer Course: Bioinformatics for Clinicians. 30.7.2014, Helsinki, Finland

Kere, J. Epigenetics and transcriptomics in asthma and allergy. Nordisk Förening för Allergologi (NFA) Scientific Symposium, Tuohilampi, Finland, 27th -29th August 2014.

L. Bennett, A. Kittas, S. Liu, L. G Papageorgiou, S. Tsoka, “Mathematical programming approaches for community structure detection: overlapping communities in protein interaction networks”, European Conference in Complex Systems, Lucca, 22-16 September 2014.

A. Kittas, A. Barozet, J. Sereshti, N. Grabe, S. Tsoka, “Logical Modelling of Signalling Networks”, Synthetic Biology Congress, London, 20-21 October 2014.

A. Kittas, A. Barozet, J. Sereshti, N. Grabe, S. Tsoka, “CytoASP: A Cytoscape plug-in for logical modelling of signalling networks using BioASP”, 13th European Conference on Computational Biology, Strasbourg, 7-10 September 2014.

G. Muirhead, F. O. Nestle, S. Tsoka, “A simultaneous analysis of the host transcriptome and microbiome at the site of skin inflammation”, British society for Investigative Dermatology, Newcastle, 7-9 April 2014.

G. Muirhead, J. Pathmanathan, L. Bennett, I. D. Wilson, J. E. Sidaway, E. Holmes, S. Tsoka “Gut Microbiota Modulate Host Gene expression at the Local and Systemic Levels”, Microbiome and Host Health, Lisbon, 12-14 May 2013.

Levi-Schaffer, F. ”Activation phenotypes are enhanced in interacting mast cells and eosinophils: Functional implications of the Allergic Effector Unit”. October 2012, 29th Symposium of the Collegium Internationale Allergologicum (CIA), Jeju Island, South Korea, (Oral Presentation).

Levi-Schaffer, F. ”The two musketeers of allergic inflammation: mast cells and eosinophils”, April 2014, “Inflammation Beyond Infection” Forum, Jerusalem, Israel, (Speaker Presentation).

Levi-Schaffer, F. ”The receptor/ligand CD48: is it a new cellular target for allergic diseases?”, August 2014, Chair and speaker in session: Immunobiologicals and chronic inflammatory diseases, IUPHAR World Congress of Basic and Clinical Pharmacology, Cape Town, South Africa, (Invited lecture)

Gangwar, R. S., Minai-Fleminger, Y. and Levi-Schaffer, F. “Regulation of CD48 in Allergic Inflammation.” September 13-17 2014, 30th Symposium of the Collegium Internationale Allergologicum: Allergies: Current challenges and solutions. Germany, (Gangwar, R.S. presented poster and won award of “Alain de Weck Travel Grant”).

Breuer, O., Barhom, A., Gangwar, R. S. … Levi-Schaffer, F. “CD48: an independent biomarker for asthma”, June 2014, CIPP XIII International congress on Pediatric Pulmonology, Bruges, Belgium. (Oral Presentation by Breuer, O.)

Minai-Fleminger, Y., Gangwar, R.S., Migalovich-Sheikhet, H., … Levi-Schaffer, F. “The CD48 receptor mediates Staphylococcus aureus induced human and murine eosinophil activation”, February 2013, Israel Immunological Society, 40th Annual Meeting, Ben-Gurion University, Beer-Sheva. (Poster presented by Minai-Fleminger, Y)

Levi-Schaffer, F. ”Pharmacotherapy of mast cell disorders”. December 2014, Speaker in Symposium on Mast Cell Disorders, 3rd World Allergy Organization International Scientific Conference, Rio de Janeiro, Brazil. (Invited speaker)

Levi-Schaffer, F. ”Inhibitory receptors on mast cells and eosinophils as new targets for anti-allergic therapy”. April 2015, Speaker in session of British Pharmacological Society Focused Meeting: Exploiting the new pharmacology and application to drug discovery, Edinburgh, Scotland, UK. (Invited speaker).

Alenius H. IL-33 and ST2 in atopic dermatitis. Sister Society Symposium, EAACI, Copenhagen, Denmark, June 7-9- 2014. Invited lecture.

Fyhrquist N, Ruokolainen L, Suomalainen A, Lehtimäki S, Veckman V, Vendelin J, Karisola P, Savinko T, Lehto M, Jarva H, Kosunen T, Corander J, Auvinen P, v Hertzen L, Laatikainen T, Mäkelä M, Haahtela T, Greco D, Hanski I, Alenius H. Acinetobacter in the skin microbiota protects from atopic sensitization. EAACI, Copenhagen, Denmark, June 7-9 2014 abstract collection.

Alenius HA. Microbes in Allergy and Autoimmunity Related to the Skin. British Society for Investigative Dermatology Annual Meeting, Novotel Southampton, 27th – 29th April 2015

Karisola P. The MAARS project and validation experiments in vivo. Nordisk Förening för Allergologi (NFA) Scientific Symposium, Tuohilampi, Finland, 27th -29th August 2014.

Suomalainen A: Pathogenic and protective effects of C. albicans and A. lwoffii in a mouse model of atopic dermatitis (NFA) Scientific Symposium, Tuohilampi, Finland, 27th -29th August 2014.

Ruokolainen, L. A systems biology approach to environmental biodiversity, human microbiota and allergy. Nordisk Förening för Allergologi (NFA) Scientific Symposium, Tuohilampi, Finland, 27th -29th August 2014.

Hanski, I. Environmental biodiversity, human microbiota and allergy are interrelated. Nordisk Förening för Allergologi (NFA) Scientific Symposium, Tuohilampi, Finland, 27th -29th August 2014.

Fyhrquist N. Acinetobacter in the skin microbiota protects from atopic sensitization. European Academy of Dermatology and Venereology (EADV)/European Society of Dermatological Research (ESDR) Summer Course: Bioinformatics for Clinicians. 30.7.2014, Helsinki, Finland

Fyhrquist N. Cellular mechanisms of skin inflammation. Finnish Society of dermatology Annual meeting, 13-14.3.2015, Helsinki. Finland

 

 

 

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