MAARS P5 HHU

The Heinrich-Heine-University (HHU) is a state-funded and research-driven University dedicated to unravel the molecular mechanisms of diseases to develop novel therapeutic strategies. To support these goals the University established the Biomedical Research Center (BMFZ) harboring centralized state-of-the-art core facilities for molecular and cellular biology including DNA sequencing, microrray analyses, proteomics etc. At the Heinrich-Heine-University, Immunity and Infections represent a special research focus which is represented by the Research Unit 729 “Anti-infectious effector programmes” and the Jürgen Manchot Graduate School “Molecule of Infection”. Dr. Homey’s group is part of the Medical Faculty of HHU which is supported by the Universitätsklinikum Düsseldorf (UKD) in carrying out its
research activities.

Research group
Dr. Homey’s group currently composed of three post-doctoral PhD fellows, four post-doctoral MD fellows, two graduate students and four technicians. Dr. Homey is the full professor of the HHU and director of the Department of Dermatology of the Universitätsklinikum Düsseldorf (UKD) as well as head of the Allergology Unit. Dr. Homey is part of several national research networks and was part of the coordination team in EU project Chemokine-Atopy. Moreover, Dr. Homey is a member of the COST action “Skin Barrier and Atopic Diseases (SKINBAD).

Main tasks of Homey group
The group of Dr. Homey will mainly participate in the characterization of clinical samples (WP1), the analysis of the molecular and cellular networks (WP5) of atopic dermatitis and psoriasis. The requested physician (UKD) and the requested technician (UKD) will be involved in tasks associated with WP1 and the requested postdoctoral fellow (HHU) will be responsible for work associated with WP5.

Previous experience relevant to the tasks
The main strength of the group is in the area molecular and cellular immunology. The lab has been focusing on the identification of disease-associated genes and unraveling the role of cytokines and chemokines in the context of allergy and autoimmunity (1-5).
1. Homey, B. et al. Nat. Med. 8:157-65, 2002.
2. Soumelis, V. et al. Nat. Immunol., 3:673-80, 2002.
3. Sonkoly, E. et al. J. Allergy Clin. Immunol. 117:411-7, 2006.
4. Wang, YH et al. J. Exp. Med., 204: 1837-47, 2007.
5. Lande, R. et al. Nature, 449:564-9, 2007.
6. Ganguly D. et al. J. Exp. Med., 206:1983-94, 2009.

A short profile of the staff-members involved in the project
Dr. Bernhard Homey. Principal Investigator; expertise in molecular and cellular immunology. Dr. Erich Buenemann. Postdoc and senior scientist with experience in project management and expertise in cellular immunology, immunohistochemistry, subcellular localization of target molecules, and dynamic cell imaging. Dr. Andreas Hippe. Postdoc with expertise in molecular biology, large scale expression analyses. Dr. Alexandra Bettina Buhren. Postdoc. Experience in cell biology, in vivo mouse models.Dr. S. Meller, Dr. Arne Gerber, Dr. G. Kukova, with experiences in immunohistochemistry and cellular immunology. Ulrike Wiesner, Sabine Kellermann, and Robert Kubitza, technicians, expertise in conducting experiment in the area of molecular and cellular biology, immunohistochemistry and dynamic cell imaging.

Read more about this group: //link to group homepage

The third party UKD is linked to the beneficiary HHU (Partner 5)
UKD is a public body (Anstalt des öffentlichen Rechts). Dr. Homey is the director of the Department of Dermatology of the UKD and head of the Allergology Unit. As specified in the law of North Rhine-Westphalia (Hochschulmedizingesetz NRW, § 3.4), the UKD is obliged to provide and carry out medical services, for the Medical Faculty of the HHU. This means to the MAARS project that all necessary medical services for the project such as selecting the appropriate patients, examination of the participant, getting the informed consent, generating samples and supervising the sample flow is supported by the requested physician who is a member of the UKD. Also the requested technical assistant is a member of the UKD. The technician assisting the physician is responsible for the post sample generating procedures.
Furthermore, the UKD supports the Medical Faculty in carrying out its research activities.

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